CREST-2 coordination for preventing strokes from carotid artery narrowing
CREST-2 Statistical and Data Coordinating Center - SDCC
This effort helps compare intensive medical treatment alone versus adding carotid surgery or carotid stenting to prevent strokes in adults with severe carotid artery narrowing.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-11145185 on NIH RePORTER |
What this research studies
This coordinating center manages the data and statistics for two large, parallel trials comparing intensive medical management alone to adding carotid endarterectomy or carotid stenting in people with severe (≥70%) carotid narrowing. Eligible patients are randomly assigned to one of the treatment approaches and followed closely for early complications (including stroke or death within 44 days) and longer-term ipsilateral stroke. The center oversees data collection from many participating hospitals, monitors quality and safety, and performs the analyses that will guide treatment recommendations. As a patient, you would enroll at a participating site and have your imaging, treatments, and outcomes recorded and shared with the coordinating center.
Who could benefit from this research
Good fit: Adults with severe (≥70%) narrowing of the carotid artery who do not have a recent disabling stroke and are being considered for surgery or stenting.
Not a fit: People without significant carotid narrowing, those with recent disabling stroke, or those ineligible for revascularization are unlikely to benefit from joining this effort.
Why it matters
Potential benefit: If successful, the results could clarify which approach best lowers stroke risk and help patients avoid unnecessary procedures or get the procedure that offers the greatest protection.
How similar studies have performed: Earlier trials from the 1980s–1990s showed benefits of carotid revascularization, but improvements in medical therapy mean this question is being reexamined in modern patients.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Edwards, Lloyd J — University of Alabama at Birmingham
- Study coordinator: Edwards, Lloyd J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.