Creating targeted antibodies for immune system interactions
Official title: Development of Conformer-Specific Anti-I-A Class II mAbs
Funded at Albany Medical College · NIH-11109993 · Data updated 2026-11-12
This study is looking at special antibodies that help us understand how our immune system works, especially how certain immune cells talk to each other, which could lead to better treatments for diseases that affect our immune responses.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albany Medical College NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project start | June 6, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $164,000 |
| NIH project number | 1R03AI190276-01 |
| Project ID | NIH-11109993 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with autoimmune diseases or conditions that affect immune responses.
✕Less likely to help
Patients with conditions unrelated to immune system function may not receive any benefit from this research.
What this research studies
This research focuses on developing specific antibodies that can bind to different forms of major histocompatibility complex (MHC) class II molecules, which play a crucial role in how immune cells interact with each other. By identifying and characterizing these antibodies, the research aims to enhance our understanding of immune responses, particularly in relation to CD4 T cells and antigen-presenting cells. The methodology involves a two-step approach to isolate and study these antibodies, which could lead to better tools for investigating immune functions in various diseases. Patients may benefit from advancements in treatments that target immune responses more effectively.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for diseases that involve immune system dysfunction.
How similar studies have gone: Previous research has shown promise in developing similar antibodies, indicating a potential for success in this area.
Where this research is happening
-
Albany Medical College
Albany, United States Active
Researchers
- Principal investigator: Drake, James R — Albany Medical College
- Study coordinator: Drake, James R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.