Creating powerful antibodies to fight HIV
Engineering of broadly reactive seroantibodies
This study is looking at new ways to create powerful antibodies that can fight different types of HIV-1, especially the kind that affects many Veterans, to help improve treatment options for people living with HIV.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baltimore VA Medical Center NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10553642 on NIH RePORTER |
What this research studies
This research focuses on developing broadly neutralizing antibodies (bNAbs) that can effectively target and neutralize various strains of HIV-1, particularly the Clade B strain prevalent among Veterans. The researchers aim to enhance the potency and breadth of these antibodies through engineering techniques, utilizing both antibody and viral envelope sequences. By testing these engineered antibodies in mouse models, the study seeks to identify potential treatments that could improve outcomes for individuals living with HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living with HIV, particularly those infected with Clade B strains.
Not a fit: Patients who are not infected with HIV or those with strains outside of Clade B may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for HIV, potentially reducing the need for lifelong antiretroviral therapy.
How similar studies have performed: Previous research has shown promise in developing broadly neutralizing antibodies for HIV, indicating potential for success with this approach.
Where this research is happening
Baltimore, United States
- Baltimore VA Medical Center — Baltimore, United States (Active)
Researchers
- Principal investigator: Sajadi, Mohammad Mohseni — Baltimore VA Medical Center
- Study coordinator: Sajadi, Mohammad Mohseni
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.