Creating new treatments to fight Pseudomonas aeruginosa infections
Development of Gene-Silencing Therapeutics for Pseudomonas aeruginosa
This study is looking at new treatments that use special molecules to help fight infections from a tough bacteria called Pseudomonas aeruginosa, especially for people with cystic fibrosis, by stopping the bacteria from growing.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10925139 on NIH RePORTER |
What this research studies
This research focuses on developing innovative gene-silencing therapies to combat infections caused by the antibiotic-resistant bacteria Pseudomonas aeruginosa. The approach involves using specialized molecules called PPMOs that block the production of proteins essential for the bacteria's growth. By targeting specific genes, the researchers aim to reduce the bacteria's ability to survive and cause infections, particularly in vulnerable patients such as those with cystic fibrosis. The project includes extensive testing in laboratory models to evaluate the effectiveness and safety of these new therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with chronic infections, especially those with cystic fibrosis or those who are immunocompromised.
Not a fit: Patients with infections caused by bacteria other than Pseudomonas aeruginosa may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients suffering from severe bacterial infections, particularly those resistant to current antibiotics.
How similar studies have performed: Previous research has shown promise in using gene-silencing techniques to combat bacterial infections, indicating potential for success in this novel approach.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Greenberg, David Elihu — Ut Southwestern Medical Center
- Study coordinator: Greenberg, David Elihu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.