Creating new tools to study type IV collagens and their role in diseases
Official title: Development of novel genetic tools for the study of type IV collagens
Funded at University of California, San Francisco · NIH-10975838 · Data updated 2026-11-12
This study is looking at how a special type of collagen, which is important for our body's structure, works and how it relates to diseases like Alport syndrome, and they're creating special mouse models to help see these collagens in action so they can learn more about these conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | August 19, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $246,000 |
| NIH project number | 1R21DK140866-01 |
| Project ID | NIH-10975838 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alport syndrome or related hereditary nephropathies.
✕Less likely to help
Patients with conditions unrelated to type IV collagens or those not affected by genetic nephropathies may not benefit from this research.
What this research studies
This research focuses on understanding how type IV collagens function in the extracellular matrix and their involvement in genetic and acquired diseases. The team aims to develop innovative genetic tools that allow for the visualization and isolation of these collagens in various biological contexts. By creating mouse models with fluorescently tagged collagens, researchers will be able to observe changes in collagen behavior over time and in different conditions, which is crucial for advancing our knowledge of related diseases. This approach could lead to better insights into conditions like Alport syndrome, which is linked to mutations in these collagens.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for diseases associated with type IV collagen mutations.
How similar studies have gone: Other research has shown promise in using genetic tools to study collagen-related diseases, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Gould, Douglas — University of California, San Francisco
- Study coordinator: Gould, Douglas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.