Creating new tools to analyze RNA modifications in cells
Official title: Develop new bioinformatics infrastructures and computational tools for epitranscriptomics data
Funded at University of Chicago · NIH-11045681 · Data updated 2026-11-12
This study is all about creating easy-to-use tools that help scientists understand how tiny changes in RNA can affect gene activity, which is important for learning more about diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | May 15, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $393,270 |
| NIH project number | 5R01HG012927-03 |
| Project ID | NIH-11045681 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with conditions influenced by RNA modifications, such as certain cancers or genetic disorders, may benefit from this research.
✕Less likely to help
Patients with conditions unrelated to RNA biology or those not affected by RNA modifications may not receive any benefit from this research.
What this research studies
This research focuses on developing advanced bioinformatics tools to analyze dynamic RNA modifications, which play a crucial role in gene expression regulation. By utilizing cutting-edge sequencing technologies, the project aims to profile RNA modifications across different conditions and cell types. The researchers will create statistical methods for detecting these modifications at a very precise level and develop user-friendly software to help scientists integrate this data with genomic features. This work is essential for enhancing our understanding of RNA biology and its implications in various diseases.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of diseases linked to RNA modifications.
How similar studies have gone: While the field of epitranscriptomics is relatively new, there have been promising developments in related areas, indicating potential for success with these innovative approaches.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Chen, Mengjie — University of Chicago
- Study coordinator: Chen, Mengjie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.