Creating new tools for delivering genes using special nanoparticles
Official title: Development of peptoid-based barcodes for in vivo high-throughput screening of targeted nucleic acid delivery
Funded at University of North Texas Hlth Sci Ctr · NIH-11160703 · Data updated 2026-11-12
This study is exploring new types of barcodes made from special molecules to help scientists track and improve how tiny particles deliver genetic material in the body, which could lead to better treatments for conditions that require gene therapy.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of North Texas Hlth Sci Ctr NIH-funded |
| Lab location | 1 site (Fort Worth, United States) |
| Project start | August 15, 2024 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $185,000 |
| NIH project number | 5R21EB036261-02 |
| Project ID | NIH-11160703 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals with genetic conditions that could benefit from advanced gene therapy techniques.
✕Less likely to help
Patients who do not have genetic disorders or conditions that require gene therapy may not benefit from this research.
What this research studies
This research focuses on developing innovative barcodes made from peptoids to enhance the delivery of genetic material using nanoparticles. By utilizing unique DNA/RNA sequences, the project aims to improve the tracking and effectiveness of these nanoparticles in biological systems. The approach involves synthesizing a library of peptoid-based barcodes that can be easily identified and quantified, allowing for more efficient studies on how well these gene delivery systems work in living organisms. This could lead to better methods for gene therapy and other biomedical applications.
Why it matters
Potential benefit: If successful, this research could significantly improve the efficiency and accuracy of gene delivery systems, potentially leading to better treatments for various genetic disorders.
How similar studies have gone: While the use of barcoding technology in gene delivery is an emerging field, similar approaches have shown promise in preliminary studies, indicating potential for success.
Where this research is happening
-
University of North Texas Hlth Sci Ctr
Fort Worth, United States Active
Researchers
- Principal investigator: Kim, Jayoung — University of North Texas Hlth Sci Ctr
- Study coordinator: Kim, Jayoung
Related research
Other NIH-funded projects on the same topics.
-
AIM-AHEAD Coordinating Center supports four core areas
This NIH grant funds a coordinating center to advance a multi-core effort that could benefit patients through streamlined research collaboration and data sharing.
-
The WNK1/OSR1 protein pathway's role in brain insulin use and age-related memory loss
This project will see if the WNK1/OSR1 protein pathway makes the aging brain use insulin and sugar less well and whether fixing that can help memory in Alzheimer’s-related conditions.
-
HBV prevention in community pharmacies: a first step in a low-resource setting
This pilot project tests whether hepatitis B screening and vaccination can be integrated into everyday community pharmacy services to reach more people.
-
Glutaredoxin and aging: how it affects cataracts and new treatment ideas
A research project explores how aging affects the lens of the eye and tests new ways to prevent or treat cataracts by studying antioxidant repair and inflammation.
-
Voltage-dependent potassium channels and tiny blood vessels in people
This NIH grant explores how special potassium channels control tiny blood vessels in adults, which could affect blood pressure and heart health.
-
Texas Center for Health Disparities: Building Leaders in Health Equity
Aims to grow and train more health disparities researchers at UNTHSC so they can better serve communities affected by AIDS, cancers, and cardiovascular diseases.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.