Creating new tools for controlling proteins with light
Official title: Develop light-oxygen-voltage (LOV) sensing optogenetics tools through novel computational approaches with experimental validation
Funded at Southern Methodist University · NIH-10661223 · Data updated 2026-11-12
This study is exploring new ways to use light to control proteins in our cells, which could help create better treatments for conditions like gene therapy, making it easier for doctors to target specific health issues.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Southern Methodist University NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | August 1, 2018 |
| Project end | May 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $444,523 |
| NIH project number | 2R15GM122013-02A1 |
| Project ID | NIH-10661223 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit would include individuals with genetic disorders or conditions that could be treated with optogenetic approaches.
✕Less likely to help
Patients with conditions that do not involve genetic components or those who are not candidates for gene therapy may not receive benefits from this research.
What this research studies
This research focuses on developing innovative optogenetic tools that utilize light-responsive proteins to control biological processes. By employing advanced computational methods, particularly deep learning techniques, the study aims to understand the mechanisms by which these proteins respond to light. The research involves simulating protein dynamics to uncover how these proteins change shape and function in response to light exposure, which could lead to new ways to manipulate cellular activities. Patients may benefit from advancements in gene therapy and targeted treatments that arise from these new tools.
Why it matters
Potential benefit: If successful, this research could lead to groundbreaking advancements in gene therapy and targeted treatments for various conditions.
How similar studies have gone: Other research has shown promising results in the field of optogenetics, indicating that this approach has the potential for significant breakthroughs.
Where this research is happening
-
Southern Methodist University
Dallas, United States Active
Researchers
- Principal investigator: Tao, Peng — Southern Methodist University
- Study coordinator: Tao, Peng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.