Understanding how cellular quality control networks keep our cells healthy
Official title: Decipher the Organization of a Multilayered Cellular Quality Control Network
Funded at Southern Methodist University · NIH-11328821 · Data updated 2026-11-12
This NIH grant explores how the body's cellular quality control systems work together to prevent disease at the molecular level.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Southern Methodist University NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | August 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $361,222 |
| NIH project number | 5R35GM150190-04 |
| Project ID | NIH-11328821 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients whose diseases involve protein misfolding, damaged organelles, or cellular stress may benefit from future therapies informed by this work.
✕Less likely to help
There is no immediate patient treatment from this grant, but findings may influence future therapies.
What this research studies
The project aims to uncover how different cellular quality control pathways interact when cells face stress and how defects in these networks contribute to human diseases. Researchers will study these pathways in human-relevant contexts to map their cooperation and identify points where intervention could help. The work will build a broader picture of how impaired quality control leads to disease, with potential implications for future therapies. The study focuses on complex cellular processes, with goals that could eventually translate into better diagnosis or treatment strategies for patients.
Why it matters
Potential benefit: A deeper understanding of cellular quality control could guide new approaches to treating diseases linked to protein and organelle damage.
How similar studies have gone: Previous work suggests multiple quality control pathways interact, supporting the potential for meaningful advances, though the specifics remain to be clarified.
Where this research is happening
-
Southern Methodist University
Dallas, United States Active
Researchers
- Principal investigator: Wu, Zhihao — Southern Methodist University
- Study coordinator: Wu, Zhihao
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.