Creating new medicines for bacterial infections and cancers
Modular synthesis of antibiotic and anticancer classes of natural products
This project focuses on making new versions of natural compounds that can fight tough bacterial infections and various cancers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11143814 on NIH RePORTER |
What this research studies
Many natural compounds show promise in fighting diseases but are hard to modify into effective medicines. Our team is developing new ways to build these complex molecules from simple ingredients in the lab. This allows us to make changes to their structure, aiming to create more powerful and effective treatments. We use detailed information about how these molecules interact with disease targets to guide our design, hoping to discover new drug candidates.
Who could benefit from this research
Good fit: This foundational chemistry work does not directly involve patients, but future clinical trials stemming from this research would seek patients with specific bacterial infections or cancers.
Not a fit: Patients not currently affected by bacterial infections or cancers, or those whose conditions are well-managed by existing treatments, would not directly benefit from this early-stage research.
Why it matters
Potential benefit: If successful, this work could lead to the discovery of new and more effective antibiotic and anticancer drugs, especially for resistant infections and hard-to-treat cancers.
How similar studies have performed: Previous work by this team on similar compounds has led to structural discoveries and potent compounds active against resistant strains in animal models.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Seiple, Ian Bass — Scripps Research Institute, the
- Study coordinator: Seiple, Ian Bass
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.