Creating new imaging tools to better understand kidney fibrosis
Developing imaging nanoprobes to advance prognosis of kidney fibrosis
['FUNDING_R03'] · YALE UNIVERSITY · NIH-10792905
This study is testing new imaging tools that can safely check for kidney damage in people with chronic kidney disease, helping doctors understand how the condition is progressing without needing to do invasive procedures like biopsies.
Quick facts
| Phase | ['FUNDING_R03'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10792905 on ClinicalTrials.gov |
What this research studies
This research focuses on developing innovative imaging nanoprobes that can noninvasively assess kidney fibrosis, a condition that worsens chronic kidney disease (CKD). By targeting macrophages, which play a crucial role in kidney fibrosis progression, these imaging tools aim to provide a more accurate prognosis and guide treatment decisions for patients with CKD. The study seeks to move away from traditional biopsy methods, which can be invasive and carry risks, towards safer imaging techniques that can monitor kidney health over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic kidney disease who are experiencing or at risk of kidney fibrosis.
Not a fit: Patients with acute kidney injury or those without chronic kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and management of chronic kidney disease, potentially slowing its progression and enhancing patient outcomes.
How similar studies have performed: Previous research has shown promise in using imaging techniques to assess kidney conditions, indicating that this approach could be a significant advancement in the field.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: XU, LEYUAN — YALE UNIVERSITY
- Study coordinator: XU, LEYUAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atherosclerotic Cardiovascular Disease, atherosclerotic disease, atherosclerotic vascular disease, Cancers, neoplasm/cancer