Creating new disinfectants to fight resistant bacteria
Official title: The Development of Novel Disinfectants to Overcome Bacterial Resistance
Funded at Villanova University · NIH-10974662 · Data updated 2026-11-12
This study is working on creating new disinfectants that are better at fighting tough bacterial infections, especially for patients who need stronger protection against germs that don't respond to regular treatments.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Villanova University NIH-funded |
| Lab location | 1 site (Villanova, United States) |
| Project start | July 22, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $359,073 |
| NIH project number | 1R15AI185860-01 |
| Project ID | NIH-10974662 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at high risk for bacterial infections, such as patients undergoing surgery or those with compromised immune systems.
✕Less likely to help
Patients who are not at risk for bacterial infections or those with non-bacterial conditions may not benefit from this research.
What this research studies
This research focuses on developing innovative disinfectants to combat bacterial infections that have become resistant to traditional treatments. The team aims to create new compounds that go beyond existing disinfectants, specifically exploring phosphorus-based alternatives to improve effectiveness and reduce toxicity. By studying how different chemical structures influence the ability to kill bacteria, the researchers hope to design disinfectants that can tackle even the most resistant strains. Patients may benefit from these advancements through improved infection control and reduced healthcare-associated infections.
Why it matters
Potential benefit: If successful, this research could lead to more effective disinfectants that significantly reduce the incidence of bacterial infections in healthcare settings.
How similar studies have gone: Other research has shown promise in developing novel disinfectants, indicating that this approach could lead to significant advancements in infection control.
Where this research is happening
-
Villanova University
Villanova, United States Active
Researchers
- Principal investigator: Minbiole, Kevin P — Villanova University
- Study coordinator: Minbiole, Kevin P
Related research
Other NIH-funded projects on the same topics.
-
Dyadic transplant self-care: how caregivers shape outcomes
A study will look at how patients awaiting lung transplants and their caregivers work together to manage post-transplant care and what this means for health and recovery.
-
Understanding how UPF1 controls RNA decay to help treat genetic diseases
A study at Villanova University looks at how a key RNA-helicase, UPF1, decides which RNA messages get destroyed, with the aim of someday influencing gene messages linked to diseases.
-
How the flagellum controls signaling, attachment, and dormancy in parasite infections
A study using a parasite model to understand how the flagellum affects signaling, sticking to surfaces, and life-stage changes that enable infection.
-
Repairing the cartilage protective layer to help osteoarthritis
Researchers are developing lab-made molecules that mimic cartilage sugars to rebuild the tiny protective layer around joint cells for people with osteoarthritis.
-
Using advanced imaging and AI to assess cognitive decline in older adults
This study is working on a new mobile app that uses advanced brain imaging and AI to help doctors better understand and diagnose mild cognitive impairment in older adults, making it easier to find the right care and support for those experiencing memory issues.
-
Targeted delivery of siRNA to treat kidney damage after blood flow restoration
This study is looking at a new way to help protect kidneys from damage that can happen during organ transplants by using tiny particles to deliver special treatments directly to the kidney cells, with the goal of reducing inflammation and improving how the blood vessels work.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.