Creating models to study lung diseases and treatments
Reconstructing native soluble cues in vascularized whole lung scaffolds
This study is exploring new ways to understand and treat serious lung diseases like ARDS and COVID-19 complications by creating models that mimic the lungs, which could help find better treatments for patients dealing with these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10896273 on NIH RePORTER |
What this research studies
This research focuses on developing advanced models to better understand and treat lung diseases such as acute respiratory distress syndrome (ARDS) and complications from COVID-19. By reconstructing the lung's vascular structure and mimicking its natural environment, the study aims to identify key factors that influence lung health and disease. The approach involves using decellularized lung scaffolds and advanced techniques like single-cell RNA sequencing to uncover important cellular signals. This innovative methodology could lead to more effective therapies for patients suffering from severe lung conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing or at risk for acute respiratory distress syndrome or related lung conditions.
Not a fit: Patients with chronic lung diseases not related to ARDS or COVID-19 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with severe lung diseases, enhancing recovery and quality of life.
How similar studies have performed: Other research has shown promise in using decellularized organ models to study various diseases, indicating that this approach has potential for success.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Yuan, Yifan — University of Maryland Baltimore
- Study coordinator: Yuan, Yifan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.