Creating long DNA fragments efficiently for genetic research
Official title: Multiplexed In Vivo DNA Assembly
Funded at Bacstitch DNA INC. · NIH-10794331 · Data updated 2026-11-12
This study is working on a new way to create long pieces of DNA more easily and affordably, which could eventually help improve treatments for genetic conditions by making better genetic therapies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Bacstitch DNA INC. NIH-funded |
| Lab location | 1 site (Los Altos, UNITED STATES) |
| Project start | October 24, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $880,191 |
| NIH project number | 5R01HG011676-04 |
| Project ID | NIH-10794331 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals with genetic disorders or those interested in cutting-edge genetic therapies.
✕Less likely to help
Patients with conditions unrelated to genetic therapies or synthetic biology may not receive direct benefits from this research.
What this research studies
This research focuses on developing a new method for synthesizing long DNA fragments in a high-throughput and cost-effective manner. By utilizing advanced microarray printing technologies and enzymatic synthesis, the project aims to overcome current limitations in DNA assembly techniques. Patients may benefit indirectly as this research could lead to advancements in genetic therapies and synthetic biology applications that improve treatment options for various genetic conditions. The methodology involves assembling DNA elements in living cells, allowing for more accurate and efficient production of genetic materials.
Why it matters
Potential benefit: If successful, this research could significantly enhance the development of genetic therapies and synthetic biology applications, leading to improved treatment options for patients.
How similar studies have gone: Other research has shown promise in similar approaches to DNA synthesis and assembly, indicating potential for success in this novel method.
Where this research is happening
-
Bacstitch DNA INC.
Los Altos, United States Active
Researchers
- Principal investigator: Levy, Sasha F — Bacstitch DNA INC.
- Study coordinator: Levy, Sasha F
Related research
Other NIH-funded projects on the same topics.
-
Hierarchical, high-throughput DNA assembly platform to accelerate synthetic biology
A company-developed method to rapidly build very long DNA sequences in bacteria, making it easier to design complex genetic systems.
-
Creating long and complex DNA using bacteria
This study is exploring a new way to create long and complicated DNA sequences using bacteria, which could help make new treatments and therapies more affordable and easier to produce for patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.