Creating long and complex DNA using bacteria
Official title: Multiplexed in vivo assembly of long and complex DNA
Funded at Bacstitch DNA INC. · NIH-10885186 · Data updated 2026-11-12
This study is exploring a new way to create long and complicated DNA sequences using bacteria, which could help make new treatments and therapies more affordable and easier to produce for patients.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Bacstitch DNA INC. NIH-funded |
| Lab location | 1 site (Los Altos, UNITED STATES) |
| Project start | July 10, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $1,068,133 |
| NIH project number | 5R44HG013067-02 |
| Project ID | NIH-10885186 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders or conditions that could benefit from advanced genetic therapies.
✕Less likely to help
Patients with conditions unrelated to genetic therapies or those who do not have access to the technologies developed may not benefit from this research.
What this research studies
This research focuses on developing a new method to synthesize long and complex DNA sequences more efficiently and cost-effectively. By using bacteria to assemble DNA blocks, the researchers aim to overcome the limitations of current techniques that are time-consuming and expensive. Patients may benefit from advancements in synthetic biology and genomics that could lead to new treatments and therapies. The approach involves introducing DNA arrays into bacteria, which then stitch these sequences together, allowing for the production of previously inaccessible genetic materials.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in synthetic biology and personalized medicine, enabling the development of new therapies and genetic treatments.
How similar studies have gone: Other research in synthetic biology has shown promise with similar methods, indicating potential for success in this novel approach.
Where this research is happening
-
Bacstitch DNA INC.
Los Altos, United States Active
Researchers
- Principal investigator: Craford, David — Bacstitch DNA INC.
- Study coordinator: Craford, David
Related research
Other NIH-funded projects on the same topics.
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Hierarchical, high-throughput DNA assembly platform to accelerate synthetic biology
A company-developed method to rapidly build very long DNA sequences in bacteria, making it easier to design complex genetic systems.
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Creating long DNA fragments efficiently for genetic research
This study is working on a new way to create long pieces of DNA more easily and affordably, which could eventually help improve treatments for genetic conditions by making better genetic therapies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.