Creating diverse cancer models to improve treatment options.
Official title: PDX Core
Funded at Virginia Commonwealth University · NIH-10890847 · Data updated 2026-11-12
This study is working to create special models using tumor samples from people of different racial and ethnic backgrounds with advanced cancers, so we can better understand how these cancers behave and respond to treatments, ultimately helping to improve care for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project start | July 19, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $301,629 |
| NIH project number | 5U54CA283762-02 |
| Project ID | NIH-10890847 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals from racial and ethnic minority groups diagnosed with advanced cancers.
✕Less likely to help
Patients who do not belong to underrepresented racial or ethnic groups or those with early-stage cancers may not benefit from this research.
What this research studies
This research focuses on developing patient-derived xenograft (PDX) models that represent diverse racial and ethnic populations, particularly those affected by advanced cancers. By collecting and expanding viable tumor tissues from underrepresented groups, the project aims to enhance the understanding of cancer characteristics and treatment responses in these populations. The research will also create a comprehensive database linking clinical and molecular data to improve personalized cancer therapies. This initiative seeks to address health disparities in cancer treatment and outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized cancer treatments for diverse populations.
How similar studies have gone: Previous research has shown success in using patient-derived models to study cancer, but this approach specifically targeting diverse populations is relatively novel.
Where this research is happening
-
Virginia Commonwealth University
Richmond, United States Active
Researchers
- Principal investigator: Koblinski, Jennifer E — Virginia Commonwealth University
- Study coordinator: Koblinski, Jennifer E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.