Creating Better Marmoset Models for Brain Diseases
A Genetic Engineering Toolbox for Marmosets (GETMarm): Development and optimization of genome editing and assisted reproduction techniques for marmoset models
This project is developing advanced genetic tools to create more accurate marmoset models for understanding complex human brain conditions like autism.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Institute of Technology NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-11093483 on NIH RePORTER |
What this research studies
Mice are useful for studying many brain functions, but some higher brain functions and disorders are better understood using models closer to humans. Marmosets are small primates that offer a promising way to study human brain diseases, including conditions like autism. This work aims to improve the methods for making precise genetic changes in marmosets, which is currently a challenging process. By making these genetic engineering techniques more efficient and controlled, we hope to create better animal models that can help us learn more about human brain disorders.
Who could benefit from this research
Good fit: This foundational work does not directly involve patient participation, but it aims to benefit patients with brain diseases, such as autistic disorder, in the future.
Not a fit: Patients not affected by brain diseases or related conditions would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of complex brain diseases like autism by providing more accurate animal models for research.
How similar studies have performed: While CRISPR/Cas systems have revolutionized genetic engineering, applying and optimizing these techniques for marmoset models, especially for complex brain disorders, is still an emerging and novel area.
Where this research is happening
Cambridge, United States
- Massachusetts Institute of Technology — Cambridge, United States (Active)
Researchers
- Principal investigator: Feng, Guoping — Massachusetts Institute of Technology
- Study coordinator: Feng, Guoping
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.