Creating and testing models for Port-Wine Birthmarks
Official title: Generation and Validation of Disease Models for Port-Wine Birthmarks
Funded at University of South Carolina at Columbia · NIH-10891726 · Data updated 2026-11-12
This study is looking at Port-Wine Birthmarks by creating special cells from patients to better understand how they work, which could help find new and improved treatments for those with this condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Carolina at Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $158,983 |
| NIH project number | 5R21AR083066-02 |
| Project ID | NIH-10891726 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under 11 years old who have been diagnosed with Port-Wine Birthmarks.
✕Less likely to help
Patients with other types of vascular malformations or those over the age of 11 may not benefit from this research.
What this research studies
This research focuses on understanding Port-Wine Birthmarks (PWB), a common type of vascular malformation that can lead to serious complications. The team will generate induced pluripotent stem cells (iPSCs) from PWB patients and differentiate them into vascular cells and organoids to study their characteristics. By developing both in vitro and in vivo models, the researchers aim to replicate the unique vascular features of PWB, which could lead to better treatment options. This approach addresses the current lack of effective models for studying this condition.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with Port-Wine Birthmarks.
How similar studies have gone: While the approach of using iPSCs and organoids is gaining traction, this specific application to Port-Wine Birthmarks is relatively novel and has not been extensively tested.
Where this research is happening
-
University of South Carolina at Columbia
Columbia, United States Active
Researchers
- Principal investigator: Tan, Wenbin — University of South Carolina at Columbia
- Study coordinator: Tan, Wenbin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.