Creating advanced mouse models to study immune responses
Official title: Next Generation Crispr Ready, HLA Class I and II Transgenic Mouse Platform
Funded at La Jolla Institute for Immunology · NIH-11097078 · Data updated 2026-11-12
This study is creating special mice that can better mimic how our immune systems work, especially how T cells respond to infections and diseases, which could help scientists find better treatments for people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | La Jolla Institute for Immunology NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $775,888 |
| NIH project number | 1R24OD038114-01 |
| Project ID | NIH-11097078 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with autoimmune diseases, cancers, or those who are interested in the immune response to infections.
✕Less likely to help
Patients who do not have conditions related to immune response or who are not involved in research studies may not benefit from this research.
What this research studies
This research focuses on developing a new type of mouse model that can better mimic human immune responses, particularly in relation to T cell activity. By using modern CRISPR technology, the researchers aim to create mice that express various human HLA class I and II molecules, which are crucial for understanding how the immune system reacts to infections, cancers, and autoimmune diseases. These mice will allow for more accurate predictions of human T cell responses, potentially leading to improved treatments and therapies. The project builds on previous successes in generating humanized mouse models and aims to enhance the precision of genetic engineering in this area.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for a range of diseases, including infections and autoimmune disorders.
How similar studies have gone: Previous research has successfully utilized HLA transgenic mice to predict human immune responses, indicating a strong foundation for this novel approach.
Where this research is happening
-
La Jolla Institute for Immunology
La Jolla, United States Active
Researchers
- Principal investigator: Shresta, Sujan — La Jolla Institute for Immunology
- Study coordinator: Shresta, Sujan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.