Creating a special mouse model to study immune cells involved in autoimmune diseases
Official title: Generation of an ILC3-specific Cre driver in mice
Funded at Ohio State University · NIH-11017786 · Data updated 2026-11-12
This study is creating a special type of mouse to help scientists learn more about a specific kind of immune cell called ILC3s, which could improve our understanding and treatment of autoimmune diseases and infections.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | February 1, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $76,388 |
| NIH project number | 5R03AI182416-02 |
| Project ID | NIH-11017786 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would be individuals with autoimmune diseases or conditions that involve immune system dysregulation.
✕Less likely to help
Patients with non-autoimmune conditions or those not affected by immune system issues may not benefit from this research.
What this research studies
This research focuses on developing a specific mouse model that allows scientists to investigate the unique roles of type 3 innate lymphoid cells (ILC3s) in immune responses and various diseases. By using advanced genetic engineering techniques, the team aims to create a mouse strain that expresses a marker specifically in ILC3s, enabling detailed studies of how these cells function in conditions like autoimmune diseases and infections. This approach will help clarify the contributions of ILC3s compared to other immune cells, potentially leading to better understanding and treatment strategies for related health issues.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapies for autoimmune diseases and other conditions influenced by immune responses.
How similar studies have gone: While the specific approach of generating an ILC3-specific Cre driver in mice is novel, similar genetic engineering techniques have shown promise in other areas of immune research.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Oltz, Eugene M — Ohio State University
- Study coordinator: Oltz, Eugene M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.