Creating a new immune booster for influenza vaccines
DEVELOPMENT OF SMALL-MOLECULE DUAL ADJUVANT SYSTEM FOR INFLUENZA VIRUS VACCINE
['FUNDING_OTHER'] · SCRIPPS INSTITUTION OF OCEANOGRAPHY · NIH-11127339
This study is testing a new helper called Fos47 to make flu vaccines work better and last longer, especially for older adults and people with ongoing health issues, so they can get stronger protection against the flu.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SCRIPPS INSTITUTION OF OCEANOGRAPHY (nih funded) |
| Locations | 1 site (La Jolla, UNITED STATES) |
| Trial ID | NIH-11127339 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a new adjuvant called Fos47 to enhance the effectiveness and longevity of influenza vaccines. Current vaccines often provide limited protection, especially for the elderly and those with chronic illnesses, necessitating annual updates to combat new virus strains. The study will evaluate Fos47's ability to improve vaccine responses in animal models, determining the best dosage, administration route, and frequency for optimal protection. Ultimately, this work aims to prepare the adjuvant for human clinical trials.
Who could benefit from this research
Good fit: Ideal candidates for this research include elderly individuals and patients with chronic diseases who are at higher risk for influenza complications.
Not a fit: Patients who are not at risk for influenza or those who have already received effective vaccinations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and longer-lasting influenza vaccines, particularly benefiting vulnerable populations.
How similar studies have performed: Previous research has shown promise in developing adjuvants to enhance vaccine efficacy, indicating potential success for this novel approach.
Where this research is happening
La Jolla, UNITED STATES
- SCRIPPS INSTITUTION OF OCEANOGRAPHY — La Jolla, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LAPEK, JENNIFER — SCRIPPS INSTITUTION OF OCEANOGRAPHY
- Study coordinator: LAPEK, JENNIFER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Chronic Disease, Communicable Diseases