Creating a model to understand task-specific dystonia in animals
Development of an Animal Model of Task Specific Dystonia
['FUNDING_R01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-10677576
This study is creating a special rodent model to better understand task-specific dystonia, a movement disorder that causes unwanted muscle contractions, so researchers can learn how genetics and repetitive movements affect the brain and find new ways to help people with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-10677576 on ClinicalTrials.gov |
What this research studies
This research aims to develop a rodent model that mimics human task-specific dystonia, a movement disorder characterized by involuntary muscle contractions. By combining genetic modifications with specific behavioral tasks, researchers will investigate how certain genetic predispositions and repetitive movements can lead to dystonic symptoms. The study focuses on understanding the underlying brain mechanisms, particularly within the basal ganglia, that contribute to this condition. This model will help in exploring potential treatments and interventions for patients suffering from dystonia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a diagnosis of task-specific dystonia, particularly those who have a genetic predisposition to the condition.
Not a fit: Patients with other forms of dystonia or those without a genetic component may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients with task-specific dystonia.
How similar studies have performed: Previous research has shown success in using animal models to study other neurological disorders, suggesting that this approach could yield valuable insights into dystonia.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DAUER, WILLIAM T. — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: DAUER, WILLIAM T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Brain Diseases, Brain Disorders, Encephalon Diseases, Intracranial CNS Disorders, Intracranial Central Nervous System Disorders