Creating a model to study human gonad development and disorders using stem cells
Official title: Pluripotent stem cell-derived organoid model of human gonad development, functions, and disorders
Funded at Henry M. Jackson Fdn for the Adv Mil/med · NIH-10931640 · Data updated 2026-11-12
This study is creating tiny, 3D models of human gonads from stem cells to learn how they grow and work, which could help us understand issues related to sex development and infertility, ultimately aiming to improve diagnosis and treatment for patients facing these challenges.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry M. Jackson Fdn for the Adv Mil/med NIH-funded |
| Lab location | 1 site (Bethesda, United States) |
| Project start | September 18, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $578,218 |
| NIH project number | 5R01HD114180-02 |
| Project ID | NIH-10931640 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with differences or disorders of sex development (DSD) or infertility issues.
✕Less likely to help
Patients without any gonadal disorders or infertility issues may not receive direct benefits from this research.
What this research studies
This research focuses on developing a three-dimensional organoid model derived from human pluripotent stem cells to investigate how human gonads develop and function. The researchers aim to characterize these organoids at various developmental stages and use advanced techniques to analyze the genetic and epigenetic profiles of the cells within them. By understanding the normal and abnormal development of gonads, this project seeks to establish standardized protocols that could help in studying disorders of sex development and infertility. Patients may benefit from insights gained through this research, which could lead to improved diagnostic and therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could provide critical insights into gonadal disorders and infertility, potentially leading to better treatment options.
How similar studies have gone: Similar approaches using organoid technology have shown promise in other areas of research, indicating potential for success in this novel application.
Where this research is happening
-
Henry M. Jackson Fdn for the Adv Mil/med
Bethesda, United States Active
Researchers
- Principal investigator: Jordan, Philip W — Henry M. Jackson Fdn for the Adv Mil/med
- Study coordinator: Jordan, Philip W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.