Creating a model of cancer patients using advanced technology
Cancer patient on a chip
This study is creating a special model that acts like real human tumors, especially for people with invasive breast cancer, so researchers can better understand how these tumors grow and test new treatments using samples from patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10880285 on NIH RePORTER |
What this research studies
This research aims to develop a sophisticated model that mimics human tumors, specifically focusing on invasive breast cancer. By integrating tumor cells with their corresponding metastatic sites, such as the lung and liver, the project will utilize advanced 3D culture techniques to create a 'cancer patient on a chip.' This model will allow researchers to study tumor behavior and test new treatments in a controlled environment that closely resembles actual human physiology. Patients with metastatic tumors will be recruited to provide surgical specimens for this innovative approach.
Who could benefit from this research
Good fit: Ideal candidates for participation are patients diagnosed with metastatic breast cancer who are undergoing surgical procedures.
Not a fit: Patients with early-stage cancer or those not undergoing surgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments by providing insights into tumor progression and drug resistance.
How similar studies have performed: Other research has shown promise in using similar 3D tumor models, indicating potential for success in this innovative approach.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Vunjak-Novakovic, Gordana — Columbia University Health Sciences
- Study coordinator: Vunjak-Novakovic, Gordana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.