Creating a human-like mouse model to study side effects of CAR-T therapy
Official title: Novel hematopoietic humanized mouse model to study CAR-T therapy-associated cytokine release syndrome
Funded at Allegheny-Singer Research Institute · NIH-10832676 · Data updated 2026-11-12
This study is creating a special mouse model to help us learn more about cytokine release syndrome, a serious side effect of CAR-T cell therapy for blood cancers, so we can find better ways to make the treatment safer and more effective for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Allegheny-Singer Research Institute NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | May 1, 2023 |
| Project end | October 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $195,610 |
| NIH project number | 5R21OD034476-02 |
| Project ID | NIH-10832676 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with refractory or relapsed B-cell leukemia who are considering CAR-T cell therapy.
✕Less likely to help
Patients who do not have B-cell leukemia or those who are not eligible for CAR-T therapy may not benefit from this research.
What this research studies
This research focuses on developing a humanized mouse model to better understand cytokine release syndrome (CRS), a severe side effect of CAR-T cell therapy used to treat certain blood cancers. By mimicking the human immune system, the study aims to investigate the mechanisms behind excessive cytokine production that can lead to serious health complications. The researchers will use this model to test new therapies that could reduce the toxic effects of CAR-T treatment, ultimately improving patient safety and outcomes.
Why it matters
Potential benefit: If successful, this research could lead to safer CAR-T therapies with fewer severe side effects for patients undergoing treatment for blood cancers.
How similar studies have gone: Other research has shown success in using humanized mouse models to study immune responses and toxicities, indicating that this approach is promising.
Where this research is happening
-
Allegheny-Singer Research Institute
Pittsburgh, United States Active
Researchers
- Principal investigator: Fan, Yong — Allegheny-Singer Research Institute
- Study coordinator: Fan, Yong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.