Creating a 3D model to study Type 1 Diabetes and its immune response
Engineering a dynamic three-dimensional in vitro platform for the investigation of human Type 1 Diabetes immunopathogenesis
This study is creating a special lab setup to see how the immune system attacks the insulin-making cells in people with Type 1 Diabetes, which could help find better treatments for the condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10909203 on NIH RePORTER |
What this research studies
This research focuses on developing a three-dimensional in vitro platform to better understand how the immune system attacks insulin-producing beta cells in Type 1 Diabetes (T1D). By mimicking the human pancreatic environment, the study aims to investigate the interactions between immune cells and islets, which are crucial for understanding the disease's progression. The approach involves engineering a system that allows for detailed observation of immune cell behavior and testing potential interventions. This could lead to more effective treatments by providing insights that traditional methods cannot offer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Type 1 Diabetes who are interested in contributing to advancements in treatment.
Not a fit: Patients with Type 2 Diabetes or other non-autoimmune forms of diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for Type 1 Diabetes by enhancing our understanding of the disease mechanisms.
How similar studies have performed: Previous research has shown promise in using 3D models for studying autoimmune diseases, indicating that this approach could yield valuable insights.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Samojlik, Magdalena M — University of Florida
- Study coordinator: Samojlik, Magdalena M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.