Creating a 3D model of a human lymph node for studying immune responses
A spatially organized microphysiological model of a human lymph node
['FUNDING_U01'] · UNIVERSITY OF VIRGINIA · NIH-10652476
This study is creating a mini version of a human lymph node to help scientists understand how our immune system works, which could lead to better treatments for autoimmune diseases.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VIRGINIA (nih funded) |
| Locations | 1 site (CHARLOTTESVILLE, UNITED STATES) |
| Trial ID | NIH-10652476 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a microphysiological model of a human lymph node, which is crucial for initiating immune responses. By using advanced techniques to culture human immune cells in a 3D environment, the researchers aim to replicate the natural organization and function of lymph nodes. This model will allow for better understanding of how antibodies are produced and how immune cells interact, potentially leading to improved therapies for autoimmune diseases. The project combines engineering and immunology to create a system that can mimic the complex dynamics of the lymph node.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune diseases or conditions that affect immune function.
Not a fit: Patients who do not have autoimmune diseases or related immune disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for autoimmune diseases by enhancing our understanding of immune responses.
How similar studies have performed: While organ-on-chip technologies have shown promise in other areas, this specific approach to modeling lymph nodes is novel and has not been extensively tested.
Where this research is happening
CHARLOTTESVILLE, UNITED STATES
- UNIVERSITY OF VIRGINIA — CHARLOTTESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: POMPANO, REBECCA R — UNIVERSITY OF VIRGINIA
- Study coordinator: POMPANO, REBECCA R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases, autoimmune disorder, autoimmunity disease