Creating 3D models of kidney injury using human cells.
Modeling of acute kidney injury in organoids.
['FUNDING_OTHER'] · VETERANS HEALTH ADMINISTRATION · NIH-11047118
This study is working on creating better 3D models of kidneys using human cells to help understand and treat acute kidney injury (AKI), especially for veterans, so that we can find safer and more effective treatments for those affected.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VETERANS HEALTH ADMINISTRATION (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-11047118 on ClinicalTrials.gov |
What this research studies
This research focuses on developing advanced 3D kidney organoid models to better understand and treat acute kidney injury (AKI), particularly in veterans. By using human kidney cells instead of animal models, the study aims to create more accurate representations of kidney function and injury. This innovative approach allows for reduced drug usage and improved testing of potential therapies, which could lead to better treatment options for patients suffering from AKI. The research addresses the high rates of AKI in the veteran population and seeks to improve clinical outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are veterans who have been diagnosed with acute kidney injury or are at high risk for developing it.
Not a fit: Patients who do not have acute kidney injury or related kidney conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for acute kidney injury, potentially reducing the risk of end-stage renal disease in patients.
How similar studies have performed: While traditional animal models have been used extensively, the use of human kidney organoids represents a novel approach that has not yet been widely tested in this context.
Where this research is happening
NASHVILLE, UNITED STATES
- VETERANS HEALTH ADMINISTRATION — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WOODARD, LAUREN ELIZABETH — VETERANS HEALTH ADMINISTRATION
- Study coordinator: WOODARD, LAUREN ELIZABETH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: acute kidney injury