Creatine and exercise to maintain muscle and slow cancer in prostate cancer
Creatine supplementation and resistance training to preserve muscle mass and attenuate cancer progression: A double-blind randomized controlled trial
This project explores if combining creatine supplements with resistance exercise can help men with advanced prostate cancer keep their muscle strength and improve their health while undergoing treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Utah State Higher Education System--University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11163569 on NIH RePORTER |
What this research studies
Men with metastatic prostate cancer often receive hormone therapy, which can lead to muscle loss, fatigue, and a decline in quality of life. This project aims to see if a combination of creatine supplementation and resistance training can help preserve muscle mass and improve overall well-being. We want to understand if this approach can also positively affect how the cancer progresses. Participants will be randomly assigned to receive either creatine or a placebo, along with a resistance training program, for 52 weeks.
Who could benefit from this research
Good fit: Ideal candidates are men with metastatic castration-sensitive prostate cancer who are currently receiving androgen deprivation therapy.
Not a fit: Patients not undergoing androgen deprivation therapy for metastatic castration-sensitive prostate cancer may not receive direct benefit from this specific intervention.
Why it matters
Potential benefit: If successful, this approach could help men with metastatic prostate cancer maintain their muscle mass, reduce fatigue, improve physical function, and potentially slow cancer progression during hormone therapy.
How similar studies have performed: Resistance training has shown success in preserving muscle mass in non-metastatic prostate cancer patients on similar therapy, and creatine has amplified exercise effects in other populations, suggesting a promising combination.
Where this research is happening
Salt Lake City, United States
- Utah State Higher Education System--University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Coletta, Adriana — Utah State Higher Education System--University of Utah
- Study coordinator: Coletta, Adriana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.