Coronary microvascular disease, brain aging, and memory in women
Official title: Project 2: CSVD and Cognition
Funded at Cedars-Sinai Medical Center · NIH-11411357 · Data updated 2026-11-12
A study at Cedars-Sinai will explore how small blood vessel problems in the heart and brain relate to cognitive decline and dementia in midlife women.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 15, 2025 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $412,285 |
| NIH project number | 5U54AG094168-02 |
| Project ID | NIH-11411357 on NIH RePORTER |
Who could benefit from this research
✓Could help
Women in midlife who have or are at risk for coronary microvascular disease and cognitive concerns may be eligible.
✕Less likely to help
People without vascular or cognitive concerns may not directly benefit from this study.
What this research studies
Researchers will examine how risk factors like high blood pressure, obesity, and aging link coronary microvascular disease to brain small vessel disease and cognitive changes. The project uses imaging, biomarkers, and clinical data to understand why these conditions cluster and how they contribute to dementia risk. Findings could point to early diagnostic signals and new interventions during midlife to protect memory and thinking. The work focuses on women, aiming to identify specific pathways that lead from vascular changes to ADRD.
Why it matters
Potential benefit: If successful, the study could lead to earlier detection and new ways to prevent dementia in midlife women.
How similar studies have gone: Prior research has linked cardiovascular and cerebrovascular disease with cognitive decline, suggesting this integrated approach could yield actionable insights.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Sati, Pascal — Cedars-Sinai Medical Center
- Study coordinator: Sati, Pascal
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.