Core B: Virology assays hub for dengue antibody study
Official title: CORE B: Viral Assays Core
Funded at University of California Berkeley · NIH-11415534 · Data updated 2026-11-12
A program that helps scientists measure how people’s dengue antibodies respond to infection and vaccines, using advanced lab tools.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | July 29, 2015 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $497,795 |
| NIH project number | 5P01AI106695-12 |
| Project ID | NIH-11415534 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with dengue exposure or vaccination history may contribute serum or samples for antibody profiling.
✕Less likely to help
Patients not contributing samples or not involved in dengue research may not directly benefit.
What this research studies
This project provides specialized, high-throughput tests and panels to analyze human antibody responses and monoclonal antibodies against dengue. It leverages a established reverse genetics system to study how antibodies recognize different dengue serotypes. The core supports multiple projects by delivering reagents and platform capabilities to profile humoral immunity. Results could inform safer, more balanced vaccines and better understanding of protection vs. enhancement in dengue infections.
Why it matters
Potential benefit: If successful, the work could improve dengue vaccine design and immune benchmarks used in vaccine trials.
How similar studies have gone: Previous dengue immune studies using similar antibody profiling approaches have advanced understanding of serotype-specific responses.
Where this research is happening
-
University of California Berkeley
Berkeley, United States Active
Researchers
- Principal investigator: Sheahan, Timothy Patrick — University of California Berkeley
- Study coordinator: Sheahan, Timothy Patrick
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.