Controlling mitotic regulators with SUMO tags in cancer biology
Official title: Temporal-spatial control of mitotic regulators by polySUMOylation
Funded at Florida State University · NIH-11381071 · Data updated 2026-11-12
A study exploring how chains of SUMO tags affect key cell-dividing proteins to understand cancer-related genome instability.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida State University NIH-funded |
| Lab location | 1 site (Tallahassee, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $330,839 |
| NIH project number | 5R01GM151447-04 |
| Project ID | NIH-11381071 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patients in this basic science grant review.
✕Less likely to help
No direct patient participation in this basic mechanistic study.
What this research studies
This project looks at how polySUMOylation changes where important mitotic regulators go during the cell cycle, which can influence how cancer develops or responds to treatment. Using yeast and molecular biology approaches, the researchers will manipulate SUMO chains to see how they relocate the RENT and CPC complexes during mitosis. The goal is to uncover the basic rules of how genome stability is maintained and how its failure contributes to cancer, with an eye toward future therapies. Findings could point to new targets to disrupt cancer cell division or enhance existing treatments.
Why it matters
Potential benefit: New insights into cancer cell division could lead to novel ways to stabilize genomes and improve therapies.
How similar studies have gone: Previous work shows polySUMOylation affects protein localization and DNA repair, supporting the potential relevance of this approach.
Where this research is happening
-
Florida State University
Tallahassee, United States Active
Researchers
- Principal investigator: Wang, Yanchang — Florida State University
- Study coordinator: Wang, Yanchang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.