Controlling inflammation in immune cells to improve autoimmune disease treatment
Post-Initiation control of transcription in inflammatory macrophages
This study is looking at how inflammation in certain immune cells can affect autoimmune diseases like rheumatoid arthritis, and it aims to find new ways to help manage this inflammation for better treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hospital for Special Surgery NIH-funded |
| Lab location | 1 site (New York, UNITED STATES) |
| Project ID | NIH-10737610 on NIH RePORTER |
What this research studies
This research investigates how inflammation in immune cells, specifically macrophages, contributes to autoimmune diseases like rheumatoid arthritis. It focuses on the mechanisms that regulate the activation and suppression of inflammatory genes, aiming to understand how these processes can be manipulated. By examining the roles of various transcription factors and kinases, the study seeks to identify potential therapeutic targets that could lead to better management of inflammation in patients. The research employs advanced techniques to analyze gene expression and cellular responses in macrophages under inflammatory conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autoimmune diseases, particularly those suffering from rheumatoid arthritis.
Not a fit: Patients with non-autoimmune inflammatory conditions or those not diagnosed with any inflammatory diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that more effectively control inflammation in autoimmune diseases, improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in manipulating inflammatory pathways in immune cells, suggesting that this approach could yield significant advancements in treatment.
Where this research is happening
New York, UNITED STATES
- Hospital for Special Surgery — New York, United States (Active)
Researchers
- Principal investigator: Rogatsky, Inez — Hospital for Special Surgery
- Study coordinator: Rogatsky, Inez
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.