Controlling blood cell production in heart disease
PROJECT 3: Remote control of hematopoiesis in CVD
['FUNDING_P01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-11012931
This study is looking at how the brain talks to the bone marrow to help control blood cell production, especially in people with heart issues like clogged arteries or heart attacks, to see if understanding this connection can improve heart health.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11012931 on ClinicalTrials.gov |
What this research studies
This research investigates how the brain communicates with the bone marrow to regulate blood cell production in the context of cardiovascular diseases like atherosclerosis and myocardial infarction. By examining specific brain regions, the study aims to understand their role in influencing the formation of immune cells that contribute to these conditions. The researchers will use advanced techniques such as chemogenetics and optogenetics to manipulate brain activity and observe the effects on blood cell production. This approach could lead to new insights into how stress and brain function impact heart health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with atherosclerosis or a history of myocardial infarction.
Not a fit: Patients without cardiovascular disease or those with unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve blood cell regulation and reduce the risk of heart-related complications.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between brain function and blood cell production, suggesting that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SWIRSKI, FILIP K — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: SWIRSKI, FILIP K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atherosclerotic Cardiovascular Disease, atherosclerotic disease