Control of NASH to HCC progression through NRF2 and FBP1 interactions
Official title: Project 1: Control of NASH to HCC progression by the NRF2-FBP1 tug-of-war
Funded at Sanford Burnham Prebys Medical Discovery Institute · NIH-11418962 · Data updated 2026-11-12
A research team is studying how NRF2 and FBP1 interact to influence the progression from fatty liver disease (NASH) to liver cancer (HCC) in people who have NASH.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 9, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $518,748 |
| NIH project number | 5P01CA281819-03 |
| Project ID | NIH-11418962 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with NASH or at risk of progression to HCC who could participate in biomarker studies or future clinical trials.
✕Less likely to help
Patients without NASH or those not eligible for subsequent translational studies may not benefit.
What this research studies
This project investigates how NRF2 and FBP1 regulate changes in liver cells during the transition from NASH to HCC. It explores how autophagy disruption and cellular stress signals contribute to cancer development, using models that mirror human disease. The goal is to uncover regulatory tricks that could be targeted to prevent or slow cancer arising from NASH.
Why it matters
Potential benefit: If successful, findings could lead to new strategies to prevent or delay liver cancer in people with NASH.
How similar studies have gone: Previous work shows NRF2 and metabolic pathways influence liver cancer, suggesting this line of investigation could yield actionable insights.
Where this research is happening
-
Sanford Burnham Prebys Medical Discovery Institute
La Jolla, United States Active
Researchers
- Principal investigator: Karin, Michael — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Karin, Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.