Computational Modeling Core for toxicology risk assessment
Official title: Computational Modeling Core
Funded at Michigan State University · NIH-11394805 · Data updated 2026-11-12
A grant-backed core provides advanced computer models to help predict how toxic chemicals affect the body and support safer health decisions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | April 1, 1997 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $279,369 |
| NIH project number | 5P42ES004911-31 |
| Project ID | NIH-11394805 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not directly patients; applicable to researchers and communities impacted by environmental toxins seeking safer exposure guidelines and risk assessments.
✕Less likely to help
Individuals not involved in toxin exposure research or clinical risk assessments may not directly benefit.
What this research studies
If you or your community are affected by environmental toxins, this core develops and refines computer-based models that simulate how chemicals travel through the body and cause effects. The team creates physiologically based PK/PD models for dioxins and related compounds, and offers bioinformatic support for large-scale biological data. They also provide training in computational toxicology so researchers can use these tools alongside laboratory studies. The work is coordinated with laboratory experiments to improve accuracy and relevance to human health risk assessments.
Why it matters
Potential benefit: The project could improve the precision of chemical risk assessments and reduce the need for animal testing by enabling better in silico predictions of human health impacts.
How similar studies have gone: Previous collaborations have shown that iterative computational–experimental approaches can improve predictive power for toxicology.
Where this research is happening
-
Michigan State University
East Lansing, United States Active
Researchers
- Principal investigator: Zhang, Qiang — Michigan State University
- Study coordinator: Zhang, Qiang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.