Comparing two medications for managing low blood pressure during major surgeries.
Official title: PHEnylephrine versus NOrepinephrine in Major NONcardiac surgery (PHENOMeNON): Foundational Studies for a Pragmatic Randomized Clinical Trial.
Funded at University of Michigan at Ann Arbor · NIH-11021098 · Data updated 2026-11-12
This study is looking at how two medications, norepinephrine and phenylephrine, help treat low blood pressure during major surgeries, and it aims to find out which one works better for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | February 16, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $171,731 |
| NIH project number | 5K23HL166685-03 |
| Project ID | NIH-11021098 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are scheduled for major non-cardiac surgeries requiring general anesthesia.
✕Less likely to help
Patients who are not undergoing major surgeries or those who do not require general anesthesia may not benefit from this research.
What this research studies
This research investigates how two different medications, norepinephrine and phenylephrine, are used to treat low blood pressure that can occur during major surgeries requiring general anesthesia. It aims to gather data on current practices and clinician opinions regarding these medications across various institutions. The findings will help develop a pilot clinical trial to determine which medication is more effective in improving patient outcomes during surgery. Patients undergoing major non-cardiac surgeries may be directly impacted by the results of this research.
Why it matters
Potential benefit: If successful, this research could lead to improved management of low blood pressure during surgeries, potentially reducing complications like kidney injury and enhancing overall patient safety.
How similar studies have gone: Previous research has shown varying success in the use of vasopressors during surgery, indicating that this area is still actively being explored and holds potential for new insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Janda, Allison Mary — University of Michigan at Ann Arbor
- Study coordinator: Janda, Allison Mary
Related research
Other NIH-funded projects on the same topics.
-
Expanding genetic testing for cancer risk in patients and families
This study is working to make it easier for cancer patients in Michigan to get genetic testing for cancer risk by improving how doctors gather family history and assess genetic risks, so that more people can receive the important evaluations they need.
-
HEARTS hypertension and diabetes care in Guatemala
This grant tests how well the HEARTS primary care model works in Guatemala to improve blood pressure and blood sugar control for patients.
-
Why the retina can sometimes heal itself and how we might help it heal
This NIH grant explores how inflammation and neural cells interact in the zebrafish retina to understand retinal neuron death and regeneration, with potential implications for human vision.
-
Integrated Heart Health: A HEARTS-based approach to hypertension and diabetes in Guatemala
A study tests a team-based, stepwise care model to improve blood pressure and blood sugar control for people with both hypertension and diabetes in Guatemala.
-
Understanding how work exposures and genes influence ALS risk
A study is building a long-term group of people at higher risk for ALS to see how their jobs, exposures at work, and genes together affect if and when the disease might develop.
-
An integrated mobile health program to reduce SAVA and mental health problems among female sex workers in Kenya
A new mobile health program aims to help female sex workers in Kenya avoid substance abuse, violence, HIV, and depression by delivering group therapy, online resources, and a peer discussion space.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.