Comparing the effectiveness and safety of surgery and medications for obesity and type 2 diabetes

Comparative Effectiveness and Safety of Metabolic/Bariatric Surgery, GLP-1, and SGLT-2 Medications for Patients with Obesity and Type 2 Diabetes

NIH-funded research Kaiser Foundation Research Institute · NIH-11051211

This study is looking at how well metabolic surgery works compared to certain medications for treating obesity and type 2 diabetes, so that patients and doctors can better understand the best options for managing these conditions, especially for those who might not always get the best care.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionKaiser Foundation Research Institute NIH-funded
Lab location1 site (Oakland, UNITED STATES)
Project IDNIH-11051211 on NIH RePORTER

What this research studies

This research investigates how effective and safe metabolic/bariatric surgery compares to medications like GLP-1 receptor agonists and SGLT-2 inhibitors for treating obesity and type 2 diabetes. By analyzing data from a large, diverse group of patients, the study aims to provide insights into the long-term outcomes of these treatment options. The goal is to help patients and healthcare providers make informed decisions about the best approaches to manage obesity and diabetes, particularly for underrepresented populations. The study will utilize real-world data to assess the risks and benefits of each treatment method.

Who could benefit from this research

Good fit: Ideal candidates for this research are adults living with obesity and type 2 diabetes, especially those from racial and ethnic minority groups or rural areas.

Not a fit: Patients who do not have obesity or type 2 diabetes may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could guide patients and doctors in choosing the most effective treatment for obesity and type 2 diabetes, potentially improving health outcomes.

How similar studies have performed: Other research has shown success in comparing treatment methods for obesity and diabetes, but this study aims to fill gaps in long-term data and representation.

Where this research is happening

Oakland, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions acute kidney injuryadult onset diabetesAdult-Onset Diabetes Mellitus
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.