Comparing the effectiveness and safety of surgery and medications for obesity and type 2 diabetes
Official title: Comparative Effectiveness and Safety of Metabolic/Bariatric Surgery, GLP-1, and SGLT-2 Medications for Patients with Obesity and Type 2 Diabetes
Funded at Kaiser Foundation Research Institute · NIH-11051211 · Data updated 2026-11-12
This study is looking at how well metabolic surgery works compared to certain medications for treating obesity and type 2 diabetes, so that patients and doctors can better understand the best options for managing these conditions, especially for those who might not always get the best care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Kaiser Foundation Research Institute NIH-funded |
| Lab location | 1 site (Oakland, UNITED STATES) |
| Project start | March 6, 2024 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $594,155 |
| NIH project number | 5R01DK135515-02 |
| Project ID | NIH-11051211 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults living with obesity and type 2 diabetes, especially those from racial and ethnic minority groups or rural areas.
✕Less likely to help
Patients who do not have obesity or type 2 diabetes may not benefit from this research.
What this research studies
This research investigates how effective and safe metabolic/bariatric surgery compares to medications like GLP-1 receptor agonists and SGLT-2 inhibitors for treating obesity and type 2 diabetes. By analyzing data from a large, diverse group of patients, the study aims to provide insights into the long-term outcomes of these treatment options. The goal is to help patients and healthcare providers make informed decisions about the best approaches to manage obesity and diabetes, particularly for underrepresented populations. The study will utilize real-world data to assess the risks and benefits of each treatment method.
Why it matters
Potential benefit: If successful, this research could guide patients and doctors in choosing the most effective treatment for obesity and type 2 diabetes, potentially improving health outcomes.
How similar studies have gone: Other research has shown success in comparing treatment methods for obesity and diabetes, but this study aims to fill gaps in long-term data and representation.
Where this research is happening
-
Kaiser Foundation Research Institute
Oakland, United States Active
Researchers
- Principal investigator: Arterburn, David Eric — Kaiser Foundation Research Institute
- Study coordinator: Arterburn, David Eric
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.