Combining immune therapies to improve brain cancer treatment
Proj. 2: Combining immune checkpoint blockade with T cell activation
This study is looking at ways to make brain cancer treatments work better by combining immune therapies with vaccines and special virus treatments, so that your immune system can fight the cancer more effectively.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10876407 on NIH RePORTER |
What this research studies
This research investigates how to enhance the effectiveness of immune checkpoint blockade therapies, specifically anti-PD-1 and CTLA-4, in treating glioblastoma (GBM), a type of brain cancer. The approach focuses on improving T cell activation and priming by combining these therapies with other treatments like vaccination and oncolytic virus therapy. By understanding the timing and combination of these therapies, the research aims to convert GBM tumors from immunologically 'cold' to 'hot', potentially leading to better patient outcomes. Patients may be involved in trials that assess these combination therapies and their effects on immune responses against tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with glioblastoma who have not responded adequately to standard therapies.
Not a fit: Patients with other types of cancer or those who have already undergone extensive treatment for glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for glioblastoma, improving survival rates and quality of life for patients.
How similar studies have performed: Previous research has shown promise in using combination therapies for other cancers, suggesting potential success for this novel approach in glioblastoma.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Chiocca, E. Antonio — Brigham and Women's Hospital
- Study coordinator: Chiocca, E. Antonio
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.