Cognitive risk profiles in aging veterans using big data for precision medicine
Official title: Cognitive Risk Profiles Among Aging Veterans: Harnessing Big Data for Precision Medicine
Funded at VA San Diego Healthcare System · NIH-11402088 · Data updated 2026-11-12
This project looks at how multiple risk factors like metabolic issues, head injuries, and genetic risks combine to affect memory and dementia in aging veterans.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA San Diego Healthcare System NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | October 1, 2026 |
| Project end | September 30, 2031 |
| Funding year | 2026 |
| NIH project number | 1IK2RD001192-01A1 |
| Project ID | NIH-11402088 on NIH RePORTER |
Who could benefit from this research
✓Could help
Veterans, especially those with metabolic syndrome, history of TBI, or genetic risk factors for ADRD (e.g., APOE ε4), who are part of VA programs or MVP data cohorts.
✕Less likely to help
Individuals without these risk factors or those not represented in VA/MVP data may see little direct benefit.
What this research studies
Aging veterans often have several health risks at once, and this study will combine large VA data assets to see how MetS, TBI, and genetic factors together influence late-life cognitive impairment and ADRD. Using data from MVP and VA EHR, researchers will model how these factors interact to predict dementia risk more accurately for individuals. The aim is to move toward personalized risk predictions that consider a patient’s full medical and genetic profile, rather than looking at each factor in isolation. This work could guide prevention and personalized care for veterans at risk of Alzheimer’s disease dementia and related conditions.
Why it matters
Potential benefit: If successful, this research could improve personalized risk prediction and inform targeted prevention and treatment strategies for veterans at risk of ADRD.
How similar studies have gone: Previous studies have shown that combining vascular, injury, and genetic risks can improve dementia risk prediction, but this project emphasizes an integrated, precision-medicine approach in a veteran population.
Where this research is happening
-
VA San Diego Healthcare System
San Diego, United States Active
Researchers
- Principal investigator: Lopez, Francesca Veanna — VA San Diego Healthcare System
- Study coordinator: Lopez, Francesca Veanna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.