Chronic blood clots after intermediate-risk pulmonary embolism: extend the PE-TRACT findings
Official title: The PE-TRACT EXTEND study: chronic thromboembolism following intermediate-risk PE
Funded at Weill Medical Coll of Cornell Univ · NIH-11278814 · Data updated 2026-11-12
A patient-focused study follows people who had an intermediate-risk pulmonary embolism to understand long-term symptoms and how the clotting process affects daily life.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 15, 2026 |
| Project end | March 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $936,356 |
| NIH project number | 1R01HL183994-01 |
| Project ID | NIH-11278814 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults previously enrolled in the PE-TRACT study who completed the 1-year follow-up and are being evaluated for post-PE symptoms.
✕Less likely to help
Patients without persistent symptoms or those not previously treated for PE may see limited direct benefit.
What this research studies
This study continues from a prior trial that treated acute PE with catheter-based therapy and now looks at long-term, exercise-related breathlessness and other problems caused by lingering clots. Researchers will use heart and lung tests, imaging, and blood analyses to categorize new chronic thromboembolism patterns and see how they relate to survival and functional limits. They will compare outcomes between those who received catheter therapy and those who did not, to see if treatment changes long-term risk. The team will also explore biological mechanisms behind chronic thromboembolism using genomic and proteomic data to identify potential targets for future care.
Why it matters
Potential benefit: If successful, the study could clarify why some patients have lasting symptoms after PE and point to treatments or monitoring that improve long-term quality of life.
How similar studies have gone: Some prior work has linked residual clots to ongoing symptoms, but this study advances understanding with detailed phenotyping and biological analyses.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Sista, Akhilesh K — Weill Medical Coll of Cornell Univ
- Study coordinator: Sista, Akhilesh K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.