Chemical biology of nitroxyl (HNO) in Bacillus subtilis and its link to bacterial redox health
Official title: Chemical Biology of Nitroxyl (HNO) in Bacillus Subtilis
Funded at Wake Forest University · NIH-11444170 · Data updated 2026-11-12
This grant explores how nitroxyl (HNO) interacts with bacterial redox chemistry to understand potential new ways to combat anthrax-causing bacteria.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $499,289 |
| NIH project number | 2R15GM151698-02 |
| Project ID | NIH-11444170 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patient participation in this grant.
✕Less likely to help
There is no direct patient enrollment or clinical trial component in this grant.
What this research studies
Researchers will study how nitroxyl (HNO) participates in redox reactions in Bacillus subtilis, focusing on interactions with bacillithiol and other redox partners. The project uses organic synthesis, analytical chemistry, enzymology, and bacteriology to map HNO’s role in cellular processes. It aims to uncover chemical pathways that could lead to novel antibiotic strategies against Bacillus species, including potential implications for anthrax disease.
Why it matters
Potential benefit: If successful, the work could reveal new targets for antibiotics and advance understanding of how redox chemistry affects bacterial survival.
How similar studies have gone: Previous studies have linked bacterial redox chemistry to antibiotic responses, but this project investigates a novel intersection with HNO in Bacillus subtilis.
Where this research is happening
-
Wake Forest University
Winston-Salem, United States Active
Researchers
- Principal investigator: King, S Bruce — Wake Forest University
- Study coordinator: King, S Bruce
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.