Changes in T cell structure related to memory and autoimmune diseases
Three-dimensional conformation changes associated with T cell memory and autoimmunity
['FUNDING_U01'] · UNIVERSITY OF WASHINGTON · NIH-10906379
This study is looking at how the shape of DNA in T cells affects memory and the development of autoimmune diseases like type 1 diabetes, with the hope of finding new ways to understand and treat these conditions.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10906379 on ClinicalTrials.gov |
What this research studies
This research investigates how the three-dimensional structure of chromatin in T cells affects memory and the development of autoimmune diseases like type 1 diabetes. By examining the roles of different T cell types, including memory stem cells, the study aims to understand how these cells contribute to chronic autoimmune conditions. The researchers will utilize advanced techniques such as ATAC sequencing to analyze chromatin accessibility and identify genetic factors involved in these processes. This work could lead to new insights into the mechanisms of autoimmunity and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with autoimmune diseases, particularly type 1 diabetes.
Not a fit: Patients with autoimmune diseases not related to T cell memory or chromatin changes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with autoimmune diseases.
How similar studies have performed: Previous research has shown promising results in understanding T cell roles in autoimmunity, suggesting that this approach could yield valuable insights.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HAWKINS, RAYMOND DAVID — UNIVERSITY OF WASHINGTON
- Study coordinator: HAWKINS, RAYMOND DAVID
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases, Brittle Diabetes Mellitus