Cardiovascular health in children with MPS I and IVA
Official title: Cardiovascular Structure and Function in the Mucopolysaccharidoses
Funded at Children's Hospital of Orange County · NIH-11372893 · Data updated 2026-11-12
This grant studies how heart and blood vessel problems develop in kids with MPS I and IVA, and how to monitor and improve their cardiovascular health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hospital of Orange County NIH-funded |
| Lab location | 1 site (Orange, United States) |
| Project start | July 15, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $790,852 |
| NIH project number | 5R01HL173371-02 |
| Project ID | NIH-11372893 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children with MPS I or IVA and age-matched healthy controls.
✕Less likely to help
Children without MPS or IVA or those unable to participate due to unrelated medical conditions may not benefit directly.
What this research studies
The project follows children with MPS I and IVA to track heart and artery structure and function over time, comparing them to healthy peers. It combines patient data with animal studies to understand how excess GAGs affect the cardiovascular system. The plan includes validating biomarkers that could predict heart-related outcomes and exploring potential therapies. A translational path is outlined that could lead to early interventions and better management of cardiovascular symptoms in these patients.
Why it matters
Potential benefit: If successful, it could lead to better monitoring, earlier treatment, and improved cardiovascular outcomes for children with MPS I and IVA.
How similar studies have gone: Past work has shown links between glycosaminoglycan accumulation and cardiovascular changes, but this project seeks deeper, prospective insights specific to MPS I/IVA.
Where this research is happening
-
Children's Hospital of Orange County
Orange, United States Active
Researchers
- Principal investigator: Wang, Raymond Yu Jeang — Children's Hospital of Orange County
- Study coordinator: Wang, Raymond Yu Jeang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.