Cardiometabolic Health in Women with HIV on DTG-Based ART Across Life Stages
Official title: Longitudinal Assessment of Cardiometabolic Outcomes in Women Living with HIV on Dolutegravir-Based Antiretroviral Therapy Across the Lifespan
Funded at Johns Hopkins University · NIH-11605886 · Data updated 2026-11-12
A long-term study following women with HIV to see how dolutegravir-based therapy affects heart and metabolic health compared with another ART regimen.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 1, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $99,835 |
| NIH project number | 3R01HL182418-01A1S1 |
| Project ID | NIH-11605886 on NIH RePORTER |
Who could benefit from this research
✓Could help
Women living with HIV, across reproductive ages including pregnancy and menopause, who are starting or switching to DTG-based or ATV/r-based ART.
✕Less likely to help
Women not on DTG- or ATV/r-based ART or without access to regular follow-up may have limited direct benefit.
What this research studies
This project follows women with HIV over five years at two Nigerian sites to understand how a dolutegravir-based ART affects blood pressure, cholesterol, blood sugar, body fat, and heart function across menopause, pregnancy, and aging. Researchers will collect blood tests, vascular and heart measurements, and compare outcomes to a different ART (ATAzr-based) option. The study aims to identify periods of higher risk and potential strategies to minimize cardiometabolic problems while maintaining HIV control. By focusing on real-world care in a high-volume setting, the study seeks to translate findings into better long-term health for WHIV.
Why it matters
Potential benefit: If successful, the study could guide safer ART choices and monitoring plans to reduce cardiometabolic risks in women living with HIV.
How similar studies have gone: Prior research suggests metabolic effects vary with ART type; this study adds longitudinal data in WHIV across life stages.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Eke, Ahizechukwu C. — Johns Hopkins University
- Study coordinator: Eke, Ahizechukwu C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.