Brain and thinking tests to predict early psychosis outcomes
Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services (BICEPS)
This project uses brain activity, eye-movement, and thinking tests to help predict outcomes for people aged 18–35 who are in specialty care for new-onset psychosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11141117 on NIH RePORTER |
What this research studies
If you join, you'll have EEG, eye-movement, and cognitive testing along with standard clinical measures early in your illness. The team will sort participants into previously defined 'Biotypes' based on these biomarker profiles and clinical information. Doctors will follow about 320 people across five coordinated specialty care clinics and check progress at 1, 6, and 12 months. The goal is to see which biomarker patterns match recovery, ongoing symptoms, or treatment resistance so care can be better matched to likely needs.
Who could benefit from this research
Good fit: Ideal candidates are people aged about 18–35 with early-course psychosis (including bipolar disorder with psychosis, schizophrenia, or schizoaffective disorder) receiving coordinated specialty care at a participating site.
Not a fit: People with long-established or chronic psychotic illness, those without psychotic symptoms, or individuals outside the study's age range are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, this could help clinicians match treatments and support to each person's likely course, improving recovery and reducing unnecessary or ineffective interventions.
How similar studies have performed: Previous BSNIP work has validated similar EEG, eye-movement, and cognitive biotypes in adult samples, but applying these biotypes specifically to early-course psychosis is a more recent and less-tested step.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Keshavan, Matcheri S. — Beth Israel Deaconess Medical Center
- Study coordinator: Keshavan, Matcheri S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.