Bone-targeted Ang1-7 for slowing breast cancer spread
Official title: Modulation of Breast Cancer Metastasis Using Bone-Targeted Delivery of a Small Anti-Cancer Peptide
Funded at Idaho State University · NIH-11386542 · Data updated 2026-11-12
A new treatment approach aims to deliver a cancer-fighting peptide directly to bone to help stop breast cancer from spreading, especially for hard-to-treat forms.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Idaho State University NIH-funded |
| Lab location | 1 site (Pocatello, United States) |
| Project start | August 15, 2025 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $174,532 |
| NIH project number | 5R16GM154736-02 |
| Project ID | NIH-11386542 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with breast cancer at high risk of metastasis or with existing bone metastases, who could participate in future clinical development.
✕Less likely to help
Patients without breast cancer or without risk of metastasis may not directly benefit from this preclinical work.
What this research studies
This project tests a bone-targeted version of Ang1-7, a peptide that may slow cancer growth and spread. By attaching Ang1-7 to a bone-targeting carrier, researchers hope to improve its stability and delivery to sites where breast cancer often metastasizes. The work involves preclinical studies using animal models to see how well this conjugate reduces metastatic activity and what safety profile it has. If successful, it could pave the way for future clinical options to prevent bone and other metastases in patients with breast cancer.
Why it matters
Potential benefit: If the approach works, patients could benefit from more effective control of breast cancer spread with potentially fewer side effects.
How similar studies have gone: Previous studies showed Ang1-7 can reduce cancer cell growth in culture and animal models, supporting feasibility for targeted delivery.
Where this research is happening
-
Idaho State University
Pocatello, United States Active
Researchers
- Principal investigator: Habashi, Ali Aghazadeh — Idaho State University
- Study coordinator: Habashi, Ali Aghazadeh
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.