Biotypes and biomarkers to predict outcomes for people with early psychosis
3/5 Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services (BICEPS)
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11144920
This project uses brain signals, eye movement tests, and thinking tests to group people with early psychosis so doctors can better predict how recovery might go.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11144920 on ClinicalTrials.gov |
What this research studies
If you join, you will have brief brain recordings (EEG), eye movement testing, and cognitive tests, along with routine clinical information collected. These measures will be used to place participants into previously identified 'biotypes' and then track how symptoms and function change at 1, 6, and 12 months. The work enrolls about 320 people receiving coordinated specialty care across five B-SNIP clinic sites. The goal is to see whether these groups can explain why some people recover quickly while others have persistent problems.
Who could benefit from this research
Good fit: People aged roughly 18–35 who are in the early course of psychosis (including bipolar disorder with psychosis, schizophrenia, or schizoaffective disorder) and are receiving coordinated specialty care at participating sites would be ideal candidates.
Not a fit: People with long-standing or chronic psychosis, or those without psychotic symptoms, are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this could help clinicians predict likely recovery paths and tailor type and intensity of treatments earlier in the illness.
How similar studies have performed: Prior B-SNIP work has validated similar EEG/eye-movement/cognitive biotypes in adults with psychosis, but applying these biotypes to predict outcomes in early psychosis over time is a newer step.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PEARLSON, GODFREY D — YALE UNIVERSITY
- Study coordinator: PEARLSON, GODFREY D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bipolar Disorder