Biomarker groups and early psychosis outcomes in specialty care
1/5 - Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services (BICEPS)
This project uses brain waves, eye movement, and thinking tests to group people with early psychosis and follows them over a year to see who improves or needs more care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11145182 on NIH RePORTER |
What this research studies
If you join, researchers will collect EEG, eye movement testing, cognitive testing, and clinical and demographic information early in the illness. They will apply previously identified 'Biotypes' to 320 people treated in coordinated specialty care across five B-SNIP sites. Participants will be followed at 1, 6, and 12 months to map recovery, treatment resistance, and functional change. The team will link biomarker groups and clinical features to different illness trajectories to support more tailored care.
Who could benefit from this research
Good fit: Ideal candidates are people in the early course of psychosis (often first-episode), typically young adults receiving care in coordinated specialty care clinics, including bipolar disorder with psychosis, schizophrenia, or schizoaffective disorder.
Not a fit: People with long-standing or chronic psychotic illness, no history of psychosis, or who cannot attend clinic visits are less likely to benefit directly from this work.
Why it matters
Potential benefit: If successful, this could help clinicians predict who will recover and who may need more intensive or different treatments early on.
How similar studies have performed: Earlier BSNIP work validated these EEG/eye movement/cognitive Biotypes in mixed psychosis samples, but using them specifically to predict early-course outcomes is a newer step.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Tamminga, Carol a — Ut Southwestern Medical Center
- Study coordinator: Tamminga, Carol a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.