Biological Systems Core for CIRCA (Center for Interdisciplinary Research in Childhood Adversity)
Official title: Biological Systems Core
Funded at Osu Center for Health Sciences · NIH-11536276 · Data updated 2026-11-12
A core grant helps researchers study how adverse childhood experiences shape biology to improve prevention and treatment of autoimmune and cardiovascular illnesses.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Osu Center for Health Sciences NIH-funded |
| Lab location | 1 site (Tulsa, United States) |
| Project start | August 1, 2016 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $540,035 |
| NIH project number | 5P20GM109097-10 |
| Project ID | NIH-11536276 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with autoimmune or cardiovascular conditions who have a history of adverse childhood experiences may benefit from future translational work.
✕Less likely to help
People without autoimmune or cardiovascular issues or without ACE histories may have indirect benefits from broader scientific advances.
What this research studies
This grant funds a core infrastructure that collects and analyzes data across genetics, immune markers, brain imaging, and physiological signals to understand how childhood adversity leads to health problems. It supports equipment, sample storage, and expert analysis so researchers can integrate diverse biological data. The goal is to accelerate discoveries that translate into better care for people affected by ACEs and related conditions.
Why it matters
Potential benefit: If successful, the core could speed up discovery of biomarkers and mechanisms linking ACEs to diseases, guiding more effective prevention and personalized therapies.
How similar studies have gone: Similar multidisciplinary cores have accelerated integration of multi-omic and imaging data in translational research.
Where this research is happening
-
Osu Center for Health Sciences
Tulsa, United States Active
Researchers
- Principal investigator: Simmons, William Kyle — Osu Center for Health Sciences
- Study coordinator: Simmons, William Kyle
Related research
Other NIH-funded projects on the same topics.
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How childhood adversity shapes brain responses during nicotine withdrawal
This project looks at how difficult childhood experiences affect brain and craving during nicotine withdrawal in adults who use ENDS (vaping).
-
Engaging and Connecting Kids and Families: Recruitment, Data Collection, and Analysis Core
A core team helps researchers study how childhood adversity affects health by recruiting families, gathering data, and sharing findings.
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CIRCA Administrative Core supports coordinating childhood adversity research
A centralized administrative hub helps organize, fund, and guide neurobiobehavioral studies on how childhood adversity affects health across generations.
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Improving Harms Reporting in Biomedical Trials to Protect Patients
This grant aims to create reliable measures for how harms are reported in clinical trials so patients can trust the safety information that guides medical decisions.
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Healthy Brain and Child Development: understanding how early experiences shape child growth
A large national effort is studying how genes and environments affect brain development in infants and young children to understand why some kids develop health problems later.
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Linking Daily Parental Experiences to Kids' Self-Regulation Growth in Preschoolers
This grant aims to understand how everyday parental experiences and stress influence preschoolers’ ability to manage emotions and behavior over time.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.